As the aging immune system becomes less efficient, senescent cells accumulate and taint healthy cells contributing to aging. Senolytic Px targets healthy senescent cell function, supports healthy apoptosis, within normal range, and the clearing out of damaged senescent cells. This unique combination of neurotropic phyto-nurients features the bioactive flavonoid, fisetin, fenugreek seed and quercitin blended with black pepper to enhance bio-availability in the gastrointestinal system.

Fisetin helps maintain healthy mitochondrial function in the presence of oxidative stress additionally preserving glutathione supply and supporting healthy cellular metabolism. It demonstrates a significant level of nerve and brain neuro protection along with boosting memory and healthy nerve cell growth, within normal range. 

Fenugreek Seed has neuroprotective activity, positive effects on lipid and glucose metabolic function, as well as a modulatory effect on cognitive functions and mood states. Fenugreek contains galactomannans, compounds which act to boost the bioavailability of fisetin.

This formula is also an excellent addition to the therapeutic plan for seniors challenged with frailty, age-related decline of metabolic and neurological functions and the aging immune system. Senolytic Px supports healthy neuronal cells, cognitive function, and mitochondrial function, within normal range, during the senior years.

What is Fisetin?

Fisetin is a bioactive flavonoid found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber. Fisetin has been shown to affect multiple pathways involved in healthy aging and is reported to act as a neurotrophic, botanical antioxidant, and neuroprotective agent. Research shows it helps maintain healthy mitochondrial function in the presence of oxidative stress, increases GSH and acts to modulate inflammatory activity against microglial cells impacting age-related decline in brain function.

What is Senescence?

Cell senescence is a natural process where a cell stops dividing due to various stressors such as aging, oxidation, or DNA damage, but it doesn’t die. This condition is often coined “zombie cell” because it continues to be metabolically active while releasing inflammatory chemicals (called SASP). SASP can spread and damage nearby healthy cells, thus contributing to aging and age-related diseases.

Developing senolytic therapies that selectively target senescent cells may help delay the onset of aging signs and symptoms and improve resiliency and longevity. Cellular senescence can affect a person’s ability to recover from injuries, withstand stress or illness and learn new information.

Senolytic treatment is often recommended as “hit and run” dosing, meaning high doses are used for a series of days each month, and then take a break for the remainder of the month.

Fisetin is now in Phase II Clinical studies to better understand its senolytic properties.