CaloCurb Clinical

Clinical Applications

• Reduces Appetite and Food Cravings

• Supports Long-Term Weight Management

• Stimulates Natural GLP-1, CCK and PYY Release

• Complements Lifestyle and Pharmaceutical Weight Loss Strategies

• Enhances Adherence to Intermittent Fasting and Time-Restricted Eating

Successful weight management is now a global health concern as more than 43% of adults are categorized as overweight or obese. Long term weight management requires lifestyle modification but often includes higher-force interventions such as pharmaceutical or surgical care. Pharmaceutical interventions are usually designed to reduce food intake by manipulating appetite; however, these interventions have long-term feasibility or safety concerns. Naturally derived compounds, with favorable safety profiles and the ability to powerfully suppress appetite and cravings, represent an appealing option for ongoing weight management.

Appetite regulation is orchestrated by a complex network of physical and chemical signals, with enteroendocrine hormones serving as some of the most powerful drivers of hunger and satiety. Under normal physiology, orexigenic hormones such as ghrelin rise during fasting and between meals, while anorexigenic hormones including GLP-1, CCK and PYY are released after eating. Specialized enteroendocrine cells in the gastrointestinal tract release these hormones in a dose- and time-dependent manner in response to nutrient intake.

In 2010, the New Zealand government funded a large grant to investigate the appetite suppressive effects of bitter plant compounds as a potential treatment option for weight management. After investigating over 1,000 different plant compounds in vitro, the researchers concluded that a native New Zealand hops extract produced the strongest TAS2R stimulation and consequential enhanced release of anorexigenic (GLP-1, CCK and PYY) hormonal response, indicating the strongest appetite suppressant effect. The researchers named the extract Amarasate^®, derived from Latin, meaning “bitter satiation.”

6X increase in baseline GLP-1, leads to 40% Decrease in cravings, 30% Decrease in hunger and 18% Reduced calorie intake.

The Science

·       Natural GLP-1 Activation

·       Targeted Delivery

·       Amarasate® is delivered via a delayed-release capsule to the intestines, where it activates bitter taste receptors on enteroendocrine cells.

·       Gut Peptide Activation

·       Bitter taste receptor stimulation significantly increases appetite and craving suppressing GLP-1, CCK and PYY.

·       Fast Results That Last

Concentrated Amarasate® works within one hour with results that last up to six hours

ALWAYS start with the Calocurb^® CLINICAL Starter pack as this pack onboards the body to the increased activation of natural satiety hormones. This pack onboards the body to the increased activation of natural satiety hormones. THEN move onto the Maintenance Program. For this reason...

BOTH PACKS are SOLD together here to provide a 2 month program at a DISCOUNT.

Directions for Use Always take on an empty stomach with a minimum of 8 ounces of water.

 CLINICAL STARTER PACK

Patients should begin Calocurb® CLINICAL using the Starter Pack. This pack onboards the body to the increased activation of natural satiety hormones.

Contains: 10 x 125 mg capsules and 50 x 250 mg capsules

Directions for Use

Day 1-2:            Take one 125 mg capsule one hour before a meal.

Day 3-4: Take one 125 mg capsule, twice daily, one hour before a meal.

Day 5: Take two 125 mg capsules, twice daily, one hour before a meal.

Day 6-30: Take one 250 mg capsule, twice daily, one hour before a meal.

 CLINICAL MAINTENANCE PACK

Contains: 60 x 250 mg capsules

Patients should continue on a dose of Calocurb® CLINICAL 250 mg twice daily, using the Maintenance Pack.

Take one 250 mg capsule, twice daily, one hour before a meal.

Always take on an empty stomach with a minimum of 8 ounces of water.