Apolipoprotein Assessment

Apolipoprotein A-1; apolipoprotein B; apolipoprotein B:apolipoprotein A-1 ratio.

Studies have shown that the ratio of apolipoprotein A-1:apolipoprotein B may correlate better with increased risk of coronary artery disease (CAD) than total cholesterol, and LDL:HDL ratio.

In 1971, Alaupovic suggested that apolipoproteins should be measured when assessing the relation of lipids and lipoproteins to CHD.² Many patients with CHD were found to have normal serum and cholesterol levels. It was postulated that the chemical composition of the lipoproteins was more important for understanding the process of CHD than their blood levels. Subsequent studies have demonstrated that apolipoproteins are better discriminators than lipids and lipoproteins in patients with CHD and their relatives.

A number of studies have shown that apo A-1 and apo B correlate better with evidence of CHD than do lipoprotein measurements alone

Reference:2. Alaupovic P. Apolipoproteins and lipoproteins. Atherosclerosis. 1971; 13(2):141-146. PubMed 5560875